Dr. Macrene Alexiades-Armenakas is a board certified dermatologist that has expertise in molecular science, clinical practice and product development. With research findings she was able to create 37 Extreme Actives, an enhanced, high performance line of anti-aging treatment creams that deliver targeted ingredients directly into the skin to reverse the signs of aging. 37 Extreme Actives is made in the USA and doesn't contain any parabens or fragrance.